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In humans, its two functional members, NAT1 and NAT2, show differences in expression patterns and substrate specificity, while the third member ( NATP) is a pseudogene. 2012).Īrylamine N-acetyltransferases ( NATs) genes are members of a small multigene family coding for enzymes that biotransform numerous compounds. Indeed, physiological differences between species, whether they emerged through demographic processes or as adaptive responses might offer insights into present-day questions regarding human health and disease ( Olson and Varki 2003 O’Bleness et al. As foreseen by Olson and Varki (2003), analyzing genetic and genomic diversity in the great apes is also providing novel insights of medical interest ( e.g., ( Enard et al. This potential to answer evolutionary questions regarding all hominid species, including our own, is extensively exploited, and notably so in the last half decade thanks to the accelerated pace at which whole genome sequences are generated ( Kuhlwilm et al. Hominid species, the so-called “great apes”, share a recent common history that makes the genomic diversity of our closest relatives highly informative in evolutionary studies on our own species and more broadly on all great apes. Overall, the results point to the evolution of divergent functions of these highly homologous genes in the different primate species, possibly related to their specific chemical/dietary environment (exposome) and we hypothesize that this is likely linked to the emergence of controlled fire use in the human lineage.Īrylamine N-acetyltransferases, multigenic family, drug metabolism, great apes, natural selection This pattern was also reflected in the results returned by selective neutrality tests, which suggest, in agreement with the predicted functional impact of mutations detected in non-human primates, stronger directional selection, presumably purifying selection, at NAT1 in modern humans, and at NAT2 in chimpanzees. Little polymorphism sharing was found among hominids, yet all species displayed high NAT diversity, but distributed in an opposite fashion in chimpanzees and bonobos ( Pan genus) compared to modern humans, with higher diversity in Pan species at NAT1 and lower at NAT2, while the reverse is observed in humans. To shed new light on such hypotheses, we investigated the genetic diversity of the three members of the NAT gene family in seven hominid species, including modern humans, Neanderthals and Denisovans. Current hypotheses hold that selective processes favoring haplotypes conferring lower NAT2 activity have been operating in modern humans’ recent history as an adaptation to local chemical and dietary environments. One member of this small gene family, NAT2, is established as the locus of the classic human acetylation polymorphism in drug metabolism. Among the many genes involved in the metabolism of therapeutic drugs, human arylamine N-acetyltransferases ( NATs) genes have been extensively studied, due to their medical importance both in pharmacogenetics and disease epidemiology. I purchased unlimited support in hopes that it would be better. Getting customer support in a timely fashion, is quite challenging. In MY world updates are worth 20% to 30% of the license price, not 80% to 90%. Response - silence.Īnd, the "upgrades" that require a re-purchase with a small discount are really just ways to collecting more money - there aren't any new features, just bug fixes and updates to support the underlying tools. I sent both support and sales an email when they tried to get me to "upgrade" explaining my dissatisfaction. When I was a Product Manager (or their boss) I would have been livid if a customer had been treated like this and would have done something. Did anyone ever say, "thanks for reporting an issue no one else was finding?" NO. Then, when build 7044 was released on of the items in the Release Notes was, "Fixed an issue where sometimes CompanionLink would un-register after a Windows Update." Did support ever tell me the issue was fixed? NO. Support ran me around and around, trying things I had already tried, and the basically talk me I was either an idiot or incompetent. Last year I reported that every time Windows was updating (member of the Windows Insider program) it was un-licensing itself. I have had multiple issues with Companionlink Express (doing Outlook to Google) either crashing, not starting properly, or un-licensing itself. Or I'll jut move everything to Google Workspace.Īnd the interface for this software just feels really old and dated. Recently an appointment that was scheduled for 5:00 in Outlook, was changed to 1:00 on my phone and when I synced it changed it back to 5:00. As is I have to manually get involved and either click re-read either deja cloud or Outlook and then manually sync my computer and and manually sync my phone and then manually sync the android calendar. What I want a piece of software to do is keep my contacts and calendar on my android devices in sync both ways in real time. I've resorted to manually weekly updating my tablet, phone and Outlook. Tech support tried to help last year and said the problem was fixed but it still wasn't resolved. I've been using this software for a few years and it has been problematic from day one. Each wing cover of the orange beetle is black, and its orange thorax has a black mark. The goldenrod soldier beetle has black markings on its wing covers and thorax, giving it a long orange body. Goldenrod soldier beetle ( Chauliognathus pennsylvanicus) The orangey-red oval wing cases, lustrous red thorax, and two prominent big black eyes on the side of its head are all identifying features of the red pumpkin beetle. Cucumbers, squash, watermelon, and muskmelon are also eaten by them. The pumpkin beetle gets its name from the fact that it feeds on plants in the gourd family, predominantly pumpkins. Because of its appetite for vegetation, it’s a kind of leaf beetle. The red pumpkin beetle is 0.2 to 0.3 inch (5 to 8 mm) in length. This little black beetle has slightly rounded wing cases, thin filiform antennae, and a black abdomen in addition to the dark orange color.īeetles and their larvae may wreak havoc on crops. The red pumpkin beetle consumes gourd plants and has a lustrous orange-red or orange-yellow elytra, sharp head, and two black pinhead eyes. Red Pumpkin Beetle ( Aulacophora foveicollis) The elongated form, orange head, thorax, legs, and reddish-orange elytra distinguish the common red soldier beetle. The orange-colored bug is most common in grasslands throughout the summer. Because it feeds on aphids and insect larvae, this orange beetle is considered a beneficial bug. This species has a soft body, unlike most flying beetles with hard wing cases. This harmless reddish-orange bug, on the other hand, will neither bite nor suck blood. The beetle is known as the bloodsucker beetle because of its dark orange, sometimes red color. The common red soldier beetle is 0.3 to 0.4 inch (8 to 10 mm) long. The flat body, black and orange antennae, gleaming orange head and thorax, and orange and black legs are all identifying characteristics of the slender oblong beetle. The common red soldier beetle has a distinctive black marking on its wing tips and is distinguished by its orange-red body. Common Red Soldier Beetle ( Rhagonycha fulva) Let’s explore the identifying characteristics of the most frequent varieties of orange beetles. Types of Orange Beetles - Identification Guide With Pictures Beetles come in over 400,000 different varieties, some of which are painted orange and black. To help distinguish between distinct species, beetles are classified into genera and species. The insect order Coleoptera includes orange beetles, as well as other beetle species. Orange beetles have six legs, two antennae, and wings, like all beetle species. Spots or stripes or irregular patterns cover the backs of certain orange beetles, while others have plain backs. The size, patterns on the wing cases (elytra), type of antennae, pronotum (thorax), and body form distinguish orange beetles from other insects. Hibiscus Harlequin Bug (Tectocoris diophthalmus).End Band Net-Winged Beetle (Calopteron terminale).Margined Burying Beetle (Nicrophorus marginatus).Spotted Asparagus Beetle (Crioceris duodecimpunctata). Soft-Winged Flower Beetle (Anthocomus equestris).Six-Spotted Neolema Beetle (Neolema sexpunctata).Flower Longhorn Beetle (Steneltytrana emarginata).Earth-Boring Scarab Beetle (Bolbocerasoma spp.).Colorado Potato Beetle (Leptinotarsa decemlineata).Cardinal Beetle (Pyrochroa serraticornis).Hadda Beetle (28-Spotted Potato Ladybug – Henosepilachna vigintioctopunctata).Asian Harlequin Lady Beetle (Harmonia axyridis).Goldenrod soldier beetle (Chauliognathus pennsylvanicus).Red Pumpkin Beetle (Aulacophora foveicollis).Common Red Soldier Beetle (Rhagonycha fulva).Types of Orange Beetles - Identification Guide With Pictures. He filmed several more movies, including his first leading role in Gangster No. His last stage work was in One More Wasted Year and Stranger's House at the Royal Court Theatre. He had roles in the television productions Killer Net and Coming Home, during which he met and dated Emily Mortimer. He continued doing work in stage and television: these included Joe Penhall's Love and Understanding, which played at London's Bush Theatre and then ran in Connecticut. When Bettany was 21, he appeared in a BBC production of Oliver Twist, playing Bill Sikes.Īfter appearing in the finale of Sean Bean's series Sharpe as William II of the Netherlands at the Battle of Waterloo, he made his film debut with a small part in Bent, a Holocaust drama which also featured Clive Owen, Jude Law, and Ian McKellen. He also appeared in the Royal Shakespeare Company's productions of Richard III, Romeo and Juliet, and Julius Caesar (for which he received a Charleson Award nomination). He made his stage debut in Stephen Daldry's acclaimed West End revival of An Inspector Calls at the Aldwych Theatre, playing the part of Eric Birling. In 1990, at the age of 19, Bettany began a three-year course at the Drama Centre London in Chalk Farm. He had dyslexia before it was recognised as a learning difficulty. After working there for a year, Bettany enrolled at the Drama Centre London. After two years, he found a new job in a home for the elderly. He lived in a small flat and earned money by playing his guitar in the streets as a busker. Soon after, Bettany dropped out of school, left home, and became a street performer in London. When Bettany was 16, his brother Matthew died at age 8 after falling onto concrete from a tennis pavilion roof at Queenswood. While his father taught at the all-girls boarding school Queenswood School, near Hatfield, Hertfordshire, the family lived on the school grounds. Bettany then experimented with other Christian denominations among which were Methodist and Church of England congregations with his father. Bettany was raised Roman Catholic, although his church attendance drifted after his confirmation. In television and theatre, Bettany has portrayed Ian Campbell, 11th Duke of Argyll in the series A Very British Scandal and Andy Warhol in the play The Collaboration in the West End, which is set to transfer to Broadway.īettany was born on in London, to Anne ( née Kettle), a stage singer, theatre teacher, and stage manager, and Thane Bettany, a dancer, actor, drama teacher and godfather to Sophie, Duchess of Edinburgh. He made his directorial debut with the film Shelter (2014), which he also wrote and co-produced. Other films in which Bettany has appeared include Dogville (2003), Wimbledon (2004), The Da Vinci Code (2006), The Tourist (2010), Margin Call (2011), Legend (2015) and Solo: A Star Wars Story (2018). He was nominated for a BAFTA Award for playing Stephen Maturin in the film Master and Commander: The Far Side of the World (2003). and Vision in the Marvel Cinematic Universe, including the Disney+ miniseries WandaVision (2021), for which he garnered a Primetime Emmy Award nomination.īettany first gained popularity for appearing in the films Gangster No. He is best known for his roles as J.A.R.V.I.S. Paul Bettany (born ) is an English actor. The AI in friendly areas now has a flimsy concept of suspicious behaviour, and you can build a hilariously conspicuous cardboard-box secrecy fort around a security terminal to hide your criminal hack. It makes up for that by interlocking it with other systems in entertaining ways: the slick, surprisingly natural third-person cover system lets you hide behind any vertical surface, including the ones you've placed there yourself. Human Revolution has that exact system – though the more cluttered levels mean it takes a while to learn which objects you can move. If you can pick up a box and stack it to reach an alternate route on the first level, you can stack every similar box in the game and reach anywhere physically possible. The soul of Deus Ex is in its systems: simple sets of rules with no scripting, no exceptions, and no accounting for what the player might do with them. And if your ears are still ringing from the last gunfight, you can slip through the next area quietly.Īnd these are just the routes the developers have planned. If you're bored of vents, you can open fire. If stealth gets too hard, you can find an easier route. The pleasure of that freedom is that it leaves major elements like pacing, challenge and variety up to the player. The man-sized air vent is a cliché, but honestly, it never stops being satisfying to bypass a locked door or a group of enemies. The main thing Human Revolution gets right is giving you options: every mission gives you a labyrinth of ways to get to your objective. And lastly, what it does better than the first game ever did (amazingly, loads). Secondly, the few things it misses (not that much). So I'll talk about it in three parts: firstly, everything that Human Revolution recaptures about the original Deus Ex (quite a lot). It is, I guess I should mention, the best game I've played in four years. Human Revolution is a prequel: a global conspiracy thriller set at a time when replacing your body parts with high-tech prosthetics is a violently controversial new trend. Despite a sequel in 2003, the first is still considered by me, this magazine, and a lot of our readers as the best game ever made. The Plasma Rifle is actually pretty good at Panchea if you don't mind murdering innocents.The Deus Ex games are first-person shooter RPGs that let you approach your objectives in a way that suits you: direct violence if you enjoy it, stealth if you don't, and throwing heavy objects around if you like getting caught, beaten and shot. The Rocket Launcher is complete garbage (a single EMP grenade dose a better job and takes 1/24 of the space), the grenade launcher is a better rocket launcher, the Laser Rifle is so overpowered its ridiculous, and the Plasma Rifle just sort of exists. Shotguns are pointless since they suck against armored hostiles, the TMP is pointless since it sucks against armored hostiles, and the sniper rifles, while cool, are so useless compared to a modded Zenith its laughable. Most of the other firearms in the game aren't particularly strong, apart from maybe the Combat Rifle and the Heavy Rifle if heavily modded. Takedowns are the most reliable, the stun gun is an instakill on any non-boss/bot in the game, and the PEPS can be useful at Panchea if you get spotted sneaking around and don't feel like restarting. The Zenith is also hilariously effective against Namir with AP rounds you can literally kill Namir with like 8-12 shots to the head depending on difficulty.Īs for non-lethal, I think the easiest way to prevent enemies from reviving their friends is literally just avoiding anyone you can (Cloak makes this trivial). You get VERY few revolver rounds, but you can get 10mm ammo pretty much instantly. I'd say the explosive Diamondback is a close second the only reason it's not the best firearm in the game is because of Missing Link. AP Zenith literally kills like 98% of the enemies in the game with a single headshot, which is absolutely unreal. Words can not express how deeply you are loved. I should have made the time to sit down and write the letter, so I am doing it now! Here it goes, this is what I want my granddaughter to know from my heart: Of course, those are all just lame excuses. I often thought about it, but it was usually after I had gone to bed for the night or was at some other location or circumstance where it could not be written at that moment. :) I love you.Well, that child is now 19 months old and I never wrote her that letter. But, I never have! I could talk to you forever.and who knows, maybe with my blog I will. Create your reality - attitude is everything. Do you choose hope? Love? Kindness? All of those opportunities are present in any moment of difficulty. Suffering is optional." Will you suffer? Will you sink? Will you succumb to the heartbreak? You don't have to. One of my favorite quotes is this: "Pain is inevitable. How you greet that moment will define the path you take. Adversity will knock on your door and you will have no choice - you must answer it. You cannot change the hardship and trust me, you will have hardship. Enjoy today.Īnd now here is my final pearl on your very long necklace of advice I have beaded for you: attitude is everything. That is both the blessing and the curse of life. Don't bank on seeing the person tomorrow. Whoever crosses your path today is who matters. Don't live for the future and don't steep in past mistakes. Cherish the fresh start, the blank page and the new chapter.Įnjoy today. That's my favorite part about going to sleep - the gift of a new day. There are so many fantastic people that will cross your path and influence you if only you let them. You do not hold back when you think there is an opportunity or something that intrigues you. I cannot tell you how much that humbles me.over and over again. You put on the tap shoes, pick up the lacrosse stick, belt out a song at an audition, bake an apple crustata and seize the day. One of your greatest attributes is your ability to "go for it". Be aware and generous in letting others know that soft and tender core. You have a softness and a tenderness but it is shielded by an outward strength. You are blessed by your feminine side.a sensitivity to the outsider, to the isolated, to the lonely. We cloaked you in those three important threads of life hoping they would take root in your heart and be a guide.īeing a woman is a gift. Your name holds faith and family and fun all within it. When you hear someone call your name, feel the strength of the multitude of amazing women named Mary that are part of your family hold within you the grace of Mary, the mother of all saints, and smile at that little bit extra we added to it: Katherine. When you look in the mirror, be grateful for your vision.notice the sun-kissed freckles of so many happy outdoor memories. Look at it and know beauty, health and strength. And even though it might hurt, that is what life is all about.īeautiful Mary Kate.cherish your body. Even if you get hurt or rejected, it is worth it.every friendship and relationship helps you to become the person you are supposed to be. I hope you let yourself open up to others, put yourself out of your comfort zone and let yourself feel deeply. My hope for you is that you will trust the world and live with your arms wide open. They contain a list of all of the files burned to the disc along with their hash and the directory on the computer in which they originated from. These files can be opened with any text editor. However, in the Japanese Wii release, many more leftover files related to the game's development on the Wii are present in the root of the game's filesystem, each of which were made at different stages in development. ELF file with debug symbols and a copy of main.dol that are both named after the game, region, and stage of development, located in the root of the disc. ELF file to run the game and document any differences.Īll Wii releases have an. She received her ceremonial markings while in New Zealand, learning from Māori spiritual experts, the Indigenous Polynesian people of New Zealand. Māori believe the head is the most sacred part of the body, and facial tattoos are a rite of passage, according to. "I steeped myself in the tradition of their facial tattoo practice in order to learn and to bring some of that knowledge back to my people," Big Eagle said.įace tattoos are an ancient tradition for many Indigenous peoples. However, the sacred practice of identity and heritage has lost its significance among Native American nations, including the Lakota and Dakota Sioux, Big Eagle's ancestry. "It's telling our stories, telling our status, our identity, and strengthening our commitment - our responsibility - to our people, in our commitment to this earth and a certain way of living that is balanced in harmony and with all integrity and respect for our relationship with Earth," Big Eagle explained. WRTV Photo: Shakkira Harris Stephanie Big Eagle is the owner and tattoo artist at Thunderbird Rising Studios in Indianapolis.Īfter Big Eagle received her first markings, she says it changed her life forever. The studio, everything that I have, the tattooing - everything came to me after that," Big Eagle said. "It's following that journey of our heart."Īlthough facial tattoos are a rite of passage among many Indigenous tribes, Big Eagle says the practice was persecuted in North America during colonization. "When we lived in harmony and balance, our tattoos were an integral part of that process," Big Eagle said.Īt which point, the ancient tradition was lost among Indigenous people.īig Eagle is helping renew and destigmatize the ancient tradition for Indigenous people in the West. MORE: 'We are people of the present': AICI leader on Native American Heritage Month Because the way people see things today is not steeped in anything that's really going to be everlasting or sustainable for the future." "For me, it was about going and thinking about the way saw things rather than the way people today see things. WRTV Photo: Shakkira Harris Author and handpoke tattoo artist Stephanie Big Eagle stands in front of a mural that depicts one of her ancestors, Chief Big Eagle (left), and prophet White Buffalo Woman (right) inside Thunderbird Rising Studios. Traditionally, when you receive an ancestral marking, it's applied by handpoking. It's a method that Indigenous people have practiced for thousands of years.īig Eagle is the traditional handpoke tattoo artist and founder of Thunderbird Rising Studios in Fountain Square. It is the first Native-owned handpoke tattoo studio and retail space in Indianapolis. "Indianapolis, Indiana is named for how many Native people used to be here. "When you fast forward to today, it's like where are we?" It was the mecca for my people back in the day," Big Eagle explained. Thunderbird Rising, located at 1339 Prospect St., exclusively features Indigenous art, photography, jewelry, and other products. Big Eagle also hopes her studio will be a place for Indigenous people to gather for events and have their voices heard. Jay-Z’s interest in Tidal appeared to wane, eventually selling a majority stake to Square (the mobile payment company set up by Twitter co-founder Jack Dorsey) in March 2021 for $297 million. West was even quicker to end his Tidal exclusive, releasing The Life Of Pablo on multiple streaming services in April 2016. Jay-Z eventually broke his own exclusives rule and returned his music to Spotify in 2019. (Photo by Jamie McCarthy/Getty Images for Roc Nation) gettyĭespite the high-profile names and incredible levels of media hype, Tidal did not become the blockbuster service it was aspiring to be. Cole onstage at the Tidal launch event #TIDALforALL at Skylight at Moynihan Station on Main New York City. NEW YORK, NY - MARCH 30: (L-R) Usher, Rihanna, Nicki Minaj, Madonna, Deadmau5, Kanye West, JAY Z. This was a release he returned to and reworked several times by adding and subtracting tracks, meaning it existed in a constant state of flux for listeners. Many of these marquee artists offered up exclusives, notably Beyoncé’s Lemonade album and West’s own Life Of Pablo album. Major names like Beyoncé, Rihanna, Daft Punk, Madonna, Deadmau5, Jack White and West himself were given stakes in the service and it was presented as an “artist-owned” vehicle that would pay higher streaming rates. This was the relaunch name of niche Scandinavia streaming service WiMP when Project Panther Bidco (fronted by Jay-Z) acquired it in 2015 for $54 million. He statement could also be a subtle diss aimed at Tidal. There is no uniform royalty rate for artists in the streaming world, just as there was no uniform deal in the days of CDs and LPs. His claim that artists get “just 12% of the money the industry makes” in streaming is simply too opaque to be really helpful.Īrtist streaming royalty rates will different enormously depending on the deal they have with their record label, if that deal has been renegotiated, if they are recouped or not (and labels are moving to change the recoupment imbalance), if they are on a major or an independent label, if they are self-releasing, if they are using a label services company and so on. West’s claim about Stem Player paying artists better and musicians wrestling back control from the established streaming services is as invigorating as it is vague. PHOTO: BRITTA PEDERSEN/dpa | usage worldwide (Photo by Britta Pedersen/picture alliance via Getty Images) picture alliance via Getty Images CES, the world's largest annual consumer technology trade show runs from 06 to 09 January 2015 and is expected to feature 3,500 exhibitors showing off their latest products and services to about 150,000 attendees. display during the 'ShowStoppers' event at the 2015 Consumer Electronics Show in Las Vegas, Nevada, USA, 06 January 2015. Now, however, multiple services are offering high-resolution streaming as standard.Ī music player 'Pono player 2' by manufacturer Pono Music, founded by musician Neil Young, is on. At the time, this audiophile strategy was swimming against the general tide of streaming which was more about convenience than sound. Artist empowerment was a happy byproduct of Pono’s central idea, but Young was really selling it as being about enhanced sonics for the listener. What was a phenomenal success initially as a Kickstarter project back in 2014, raising over $6 million in pledges to get it off the ground, seemed to steadily run out of steam thereafter. In that sense, the ghost of Neil Young’s Pono player raises its head. He is positioning Stem Player as being about artist empowerment over and above fan interactivity. This makes the moves here by West all the more intriguing. It was fine for a competition or a piece of interactive fan marketing, but it was never going to travel far outside of that. That said, this was, by definition, an incredibly niche activity and was never going to be a dominant way of consuming music. There was also a brief flurry of activity around browser-based interactive remixing, presenting it as a new type of musical format, with MXP4 being one of the better known examples. This all has echoes of trends from the early 2000s when acts would release stems of tracks and offer them out to fans usually as part of a remix competition, with Radiohead being one of the biggest acts to experiment here several times. The twist with the player is that it lets users interact with the tracks as they play them, with four channels that can turn up or down different parts of the track (using the stems) to get the particular sound they want. |
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